Biofilm Research

bioFILM PA ^TM

A Breakthrough in Susceptibility Testing Coming Soon!

bioFILM PA™ antimicrobial susceptibility kit

Watch Video

Biofilm Research ~ Publications

References used within the web site text that are related in MBEC/Innovotech.

Biology and Management of Microbial Biofilms on Plant Surfaces

ASTM E2799 - 11 Standard Test Method for Testing Disinfectant Efficacy against Pseudomonas aeruginosa Biofilm using the MBEC Assay

bioFILM PA ™

Migrating Microbes. European Biopharmaceutical Review, Winter 2011

Nature Protocols Paper (on the MBEC assay)

10 June 2010 - Microtiter susceptibility testing of microbes growing on peg lids: a miniaturized biofilm model for high-throughput screening.

Read the full publication at nature.com

About Us Page: under "History"

PARAHITIYAWA, N. B., SAMARANAYAKE, Y. H., SAMARANAYAKE, L. P., YE, J., TSANG, P. W. K., CHEUNG, B. P. K., YAU, J. Y. Y. & YEUNG, S. K. W. (2006)Interspecies variation in Candida biofilm formation studied using the Calgary biofilm device. Apmis 114 (4), 298-306.
Investigating the suitability of the Calgary Biofilm Device for assessing the antimicrobial efficacy of new agents
The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms
The MBEC Assay™ System: multiple equivalent biofilms for antibiotic and biocide susceptibility testing

"Antibiotic, Antimicrobial and Biocide Resistance"

Biofilm bacteria: formation and comparative susceptibility to antibiotics.
Harrison et. al. 2005. Microbiology. Persister cells mediate tolerance to metal oxyanions in Escherichia coli. 151: 3181-3195
Harrison, J. J., Turner, R. J. and H. Ceri. 2005. BioMed Central Microbiology. High-throughput metal susceptibility testing of microbial biofilms. 5: 53
Harrison, J. J., Turner, R. J., and H. Ceri. 2005. Environmental Microbiology. Persister cells, the biofilm matrix and tolerance to metal cations in biofilm and planktonic Pseudomonas aeruginosa. 7: 981-994
Robin, P. 2005. Clinical Orthopaedics and Related Research. Biofilms and Antimicrobial Resistance. 437: 41-47
Toney, J. H. And M. L. Koh. 2006 Journal of the Association for Laboratory Automation. Inhibition of Xylella fastidiosa Biofilm Formation via Metal Chelators. 11: 30-32
Halwani, M., Yebio, B., Suntres, Z. E., Alipour, M., Azghani, A. O., and A. Omri. 2008. Journal of Antimicrobial Chemotherapy. Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa. 62: 1291-1297
Tremaroli, V., Fedi, S., Turner, R., Ceri, H., and Zannoni, D. 2008. Archives of Microbiology. Pseudomonas pseudoalcaligenes KF707 upon biofilm formation on a polystyrene surface acquire a strong antibiotic resistance with minor changes in their tolerance to metal cations and metalloid oxyanions. 190: 29- 39
Belley et. al. 2009. Antimicrobial agents and Chemotherapy. Oritavancin Kills Stationary-Phase and Biofilm Staphylococcus aureus Cells In Vitro. 53: 918-925
Borras, M. 2009. Peritoneal Dialysis International. Antibiotic Resistance in Gram-Negative peritonitis. 29: 274-276
Carson et. al. 2009. Green Chemistry. Antibiofilm activities of 1-alkyl-3-methylimidazolium chloride ionic liquids. 11: 492-497
Gittard et. al. 2009. Applied Surface Science. Assessing the antimicrobial activity of zinc oxide thin films using disk diffusion and biofilm reactor. 225: 5806-5811
Hetrick, E. M., Shin, J. H., Paul, H. S. and M. H. Schoenfisch. 2009. Biomaterials. Antibiofilm efficacy of nitric oxide-releasing silica nanoparticles. 30: 2782-2789
LaPlante, K. L. and J. Woodmansee. 2009. Antimicrobial Agents and Chemotherapy. Activities of Daptomycin and Vancomycin Alone and in Combination with Rifampin and Gentamicin against Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Isolates in an Experimental Model of Endocarditis. 53: 3880-3886.
LiPuma et. al. 2009. Antimicrobial Agents and Chemotherapy. In Vitro Activities of a Novel Nanoemulsion against Burkholderia and Other Multidrug-Resistant Cystic Fibrosis-Associated Bacterial Species. 53: 249-255
Wong, H. S., Townsend, K. M., Fenwick, S. G., Trengove, R. D., and R. M. O’Handley. 2009. Journal of Applied Microbiology. Comparative susceptibility of planktonic and 3-day-old Salmonella Typhimurium biofilms to disinfectants. 108: 2222-2228.
Pratten, J. And D. Ready. 2010. Antibiotic Resistance Protocols. Use of Biofilm Model Systems to Study Antimicrobial Susceptibility. 203-215
Sawasdidoln et. al. 2010. Public Library of Science. Growing Burkholderia pseudomallei in Biofilm Stimulating Conditions Significantly Induces Antimicrobial Resistance. 5: e9196

Services Page: under "Agricultural Diseases"

1.Marques, L. R., Olson, M. E., Ceri, H., Harding, M. W., Allan, N.D., and Earle,M. L. 2006. Phytopathology. Novel methods for high-throughput screening and efficacy testing of pesticides, fungicides and difinfectants – Identifying anti-biofilm products. 96

Services Page: under "Food Safety"

Products under "Main"

Bardouniotis, Elias, Huddleston, William, Ceri, Howard & Olson, Merle E (2001)Characterization of biofilm growth and biocide susceptibility testing of Mycobacterium phlei using the MBEC Assay™ system. FEMS Microbiology Letters 203 (2), 263-267.
Minimum inhibitory concentration (MIC) versus mimimum biofilm eliminating concentration (MBEC) in evaluation of antibiotic sensitivity of gram-negative bacilli causing peritonitis
Harrison, Joe J, Ceri, Howard, Stremick, Carol & Turner, Raymond J (2004)Differences in biofilm and planktonic cell mediated reduction of metalloid oxyanions. FEMS Microbiology Letters 235 (2), 357-362.
Biofilm susceptibility to metal toxicity
Metal resistance in Candida biofilms
MELCHIOR, M. B., FINK-GREMMELS, J. & GAASTRA, W. (2006)Comparative Assessment of the Antimicrobial Susceptibility of Staphylococcus aureus Isolates from Bovine Mastitis in Biofilm Versus Planktonic Culture. Journal of Veterinary Medicine Series B 53 (7), 326-332.
A novel technique for evalutating the activity of biocides against biofilm bacteria
High throughput metal susceptibility testing of microbial biofilms
Harrison, Joe J., Turner, Raymond J. & Ceri, Howard (2005)Persister cells, the biofilm matrix and tolerance to metal cations in biofilm and planktonic Pseudomonas aeruginosa. Environmental Microbiology 7 (7), 981-994.
Quorum-Sensing Mutations Affect Attachment and Stability of Burkholderia cenocepacia Biofilms
The GacS sensor kinase controls phenotypic reversion of small colony variants isolated from biofilms of Pseudomonas aeruginosa PA14
Effects of the twin-arginine translocase on the structure and antimicrobial susceptibility of Escherichia coli biofilms

1.Harrison et. al. 2005. Canadian Journal of Microbiology. Effects of the twin-arginine translocase on the structure and antimicrobial susceptibility of Escherichia coli biofilms. 51: 671-683
1.Tomlin et. al. 2005. Applied and Environmental Microbiology. Quorum-Sensing Mutations Affect Attachment and Stability of Burkholderia cenocepacia Biofilms. 71: 5208-5218
Ali, L., Khambaty, F., and G. Diachenko. 2006. Bioresource Technology. Investigating the suitability of the Calgary Biofilm Device for assessing the antimicrobial efficacy of new agents. 97: 1887-1893
Church, D., Elsayed, S., Reid, O., Winston, B., and R. Lindsay. 2006. Clinical Microbiology Reviews. Burn Wound Infections. 19: 403-434
Pace, J. L., Rupp, M. E., and R. G. Finch. 2006. Biofilm, Infection, and Antimicrobial Therapy. Coagulase-Negative Staphylococci, Chapter 7: 109-155.
Pace, J. L., Rupp, M. E., and R. G. Finch. 2006. Biofilm, Infection, and Antimicrobial Therapy. Minimal Biofilm Eradication, Chapter 13.
Pace, J. L., Rupp, M. E., and R. G. Finch. 2006. Biofilm, Infection, and Antimicrobial Therapy. Biofilms: Background, Significance, and Roles of Catheters and Indwelling Devices. Section 1.
Zhao, J., Li, J. Y., Zhu, B., Zhou, X. D., and X. R. Xiao 2006. West China Journal of Stomatology. Study of susceptibility of oral bacteria biofilm to traditional Chinese drug preventing preventing caries. 24: 546-550
Cross, J. L., Ramadan, H. H. And J. G. Thomas. 2007. Otolaryngology—Head and Neck Surgery. The Impact of a cation channel blocker (furosemide) on Pseudomonas aeruginosa PAO1 biofilm architecture. 137: 21-26
Doring et. al. 2007. Journal of Cystic Fibrosis. Clinical trials in cystic fibrosis. 6: 85-99
Melchior, M. B., Fink-Gremmels, J., and W. Gaastra. 2007 Veterinary Microbiology. Extended antimicrobial susceptibility assays for Staphylococcus aureus isolate from bovine mastitis growing in biofilms. 125: 141-149
Tillotson, G. 2007. IDrugs. Anti-Infectives Partnering & Deal Making. 10: 249-252
Yalavarthy, R. And I. Teitelbaum. 2007. Peritoneal Dialysis International. Sterile Peritonities with Monocytic Predominance Secondary to Acute Rejection of a Previously Failed Renal Allograft. 27: 464-468
Phillips et. al. 2008. WoundHealing Southern Africa. Bacterial biofilms in wounds. 1: 10-12
Clauss et. al. 2010. Acta Biomaterialia. Biofilm formation on bone grafts and bone graft substitutes: Comparison of different materials by a standard in vitro test and microcalorimetry.
D’Alvise, P. W., Melchiorsen, J., Porsby, C. H., Nielsen, K. F. And L. Gram. 2010. Applied and Environmental Microbiology. Inactivation of Vibrio anguillarum by attached and planktonic Roseobacter. 76: 2366-2370